EG-1 interacts with c-Src and activates its signaling pathway

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EG-1 interacts with c-Src and activates its signaling pathway.

EG-1 is significantly elevated in breast, colorectal, and prostate cancers. Overexpression of EG-1 stimulates cellular proliferation, and targeted inhibition blocks mouse xenograft tumor growth. To further clarify the function of EG-1, we investigated its role in c-Src activation. We observed that EG-1 overexpression results in activation of c-Src, but found no evidence that EG-1 is a direct Sr...

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ژورنال

عنوان ژورنال: International Journal of Oncology

سال: 2006

ISSN: 1019-6439,1791-2423

DOI: 10.3892/ijo.29.4.1013